Shi Zhengli’s discovery of HKU5-CoV-2 in bats raises concerns about the potential for new pandemics.
Discovery of HKU5-CoV-2
Chinese researchers have identified a new coronavirus, HKU5-CoV-2, originating in bats, with potential for animal-to-human transmission. This discovery, led by Shi Zhengli, deepens concerns regarding zoonotic diseases. HKU5-CoV-2 is a new lineage of the HKU5 coronavirus and shares similarities with the SARS-CoV-2 virus, particularly in utilizing the ACE2 receptor, which is crucial for infecting human cells.
🤔A new bat coronavirus that has the capacity to spread to humans, similar to the one that caused the COVID-19 pandemic, has been discovered.
HKU5-CoV-2 was found by a Chinese research team led by virologist Shi Zhengli, known as "Batwoman" for her work on coronaviruses,… pic.twitter.com/tcxCNYypjc
— Camus (@newstart_2024) February 21, 2025
Initial findings are from tests showing that HKU5-CoV-2 can bind with human ACE2 receptors. However, its efficacy in these interactions is weaker than SARS-CoV-2, suggesting a lower risk for widespread human transmission. The Wuhan Institute of Virology played a significant role in this research, intensifying the discourse around the origins and potential impacts of such viral discoveries.
Scientific Implications and Concerns
Current studies indicate HKU5-CoV-2’s potential to infect human cells. Despite its ability to interact with ACE2 receptors in humans, bats, and other animals, researchers stress the virus’s limited potency compared to SARS-CoV-2. They caution against overstating its threat to public health.
New bat Coronavirus could spread like Covid-19, warns Chinese team
Led by the notorious "Batwoman" Shi Zhengli, a Chinese team discovered the new Coronavirus with the potential for animal-to-human transmission, using the same receptor as Covid-19, CGTN reports. pic.twitter.com/LPieiW3Td9
— RT (@RT_com) February 21, 2025
“The risk of [HKU5-CoV-2] emergence in human populations should not be exaggerated” – the researchers.
However, understanding the virus’s potential animal-to-human transmission remains vital for pandemic preparedness. Studies hint at frequent cross-species viral transmissions, emphasizing the significance of wildlife monitoring. Improved surveillance systems can help track such transmissions, offering invaluable data for preventing future pandemics.
Importance of Wildlife Monitoring
HKU5-CoV-2 belongs to the merbecovirus subgenus, which is related to the virus responsible for Middle East Respiratory Syndrome (MERS). Such findings highlight the genetic diversity and transmission dynamics in viral ecosystems, underscoring the necessity of wildlife monitoring. Regular surveillance could thwart potential zoonotic spillovers, which is crucial for safeguarding public health against emerging viral threats.
“We report the discovery and isolation of a distinct lineage (lineage 2) of HKU5-CoV, which can utilize not only bat ACE2 but also human ACE2 and various mammalian ACE2 orthologs,” – the scientists.
Shi Zhengli’s research fortifies the importance of wildlife monitoring. By understanding these interactions, scientists can develop strategies to mitigate viral threats, forestalling catastrophic scenarios.
Sources:
https://www.sciencedirect.com/science/article/abs/pii/S0092867425001448
